Darrin P. Lewis, Ph.D. Postdoctoral Research Fellow Cold Spring Harbor Laboratory Zhang Lab / Stanley Institute One Bungtown Road Cold Spring Harbor, NY 11724 Office: 124 Hershey Phone: 516.367.8395

Advisors

Research

Computational Biology Interests

• Genome-wide association studies
• Genomic structural variation
• Protein-protein interaction prediction
• Protein function prediction
• Micro-array gene expression analysis

Machine Learning Interests

• Large margin generative probabilistic models
• Kernel methods
• Transductive and semi-supervised learning
• Nearest Neighbor classifiers
• Approximate Bayes optimal linear classifiers

Selected Papers

• Darrin P. Lewis, Tony Jebara, and William Stafford Noble. "Support vector machine learning from heterogeneous data: an empirical analysis using protein sequence and structure." Bioinformatics, 22(22), November 2006 .
• Darrin P. Lewis, Tony Jebara, and William Stafford Noble. "Nonstationary Kernel Combination." Proceedings of the International Conference on Machine Learning, June 25-29, 2006, Pittsburgh, PA.
• Darrin P. Lewis and William Stafford Noble. "Large Margin Prediction of Protein-Protein Interactions." NIPS 2003 Workshop on New Methods in Bioinformatics.
• Darrin P. Lewis and William Stafford Noble. "Regularized nearest neighbor." NIPS 2003 Workshop on Approximate Nearest Neighbor Techniques (Poster presentation).
• Qin, Jie, Darrin P. Lewis and William Stafford Noble. "Kernel hiearchical gene clustering from microarray expression data." Bioinformatics. 19(16):2097-2104, 2003.
• Pavlidis, Paul, Darrin P. Lewis and William Stafford Noble. "Exploring gene expression data with class scores." Proceedings of the Pacific Symposium on Biocomputing, January 2-7, 2002.

My Columbia University Web Page

Research Statement

Internal